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, associate professor of , and his team have pioneered new screening platforms and new methods to evaluate therapeutic candidates, as explained in the video above.
Hepatitis B virus affects over 250 million people worldwide, damages the liver and can cause liver cancer. Hepatitis E virus can cause liver failure in immunocompromised individuals and be life-threatening during pregnancy. Most of the world’s 20 million cases occur in developing countries.
Ploss and his team have developed a new high-throughput screen to identify small molecules capable of interfering with the life cycle of hepatitis B virus. For hepatitis E virus, Ploss and his team have developed a system for culturing the virus in human liver cells in the lab. They use these methods to identify new strategies to attack the virus and rapidly screen for potential treatments.
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